List of Benchmark Dose Models
Most of the models on this page were developed by U.S. EPA and are available in BMDS 3.x, unless otherwise noted. The BMDS User Guide thoroughly describes these models, including the differences between frequentist and Bayesian modeling.
Some models are flagged as available only in BMDS 2.7. The BMDS 2.7 software is available for download, but is no longer supported or updated by EPA.
On this page:
- Frequentist Continuous Models
- Frequentist Dichotomous Models
- Frequentist Nested Dichotomous Models
- Specialized Models
- Models No Longer Supported
Frequentist Continuous Models
- Exponential
- Hill
- Linear
- Polynomial
- Power
Frequentist Dichotomous Models
- Gamma
- Logistic
- Log-Logistic
- Log-Probit
- Multistage
- Probit
- Weibull
- Quantal Linear
- Dichotomous Hill
- Quantal Models with Background Dose Parameter (BMDS 2.7 only)
Frequentist Nested Dichotomous Models
- Nested Logistic
- National Center for Toxicological Research (NCTR) (BMDS 2.7 only)
- Rai and Van Ryzin (No longer supported; BMDS 2.7 only)
Specialized Models
- Bayesian model averaging (dichotomous)
- Multi-tumor (MS_Combo)
- 2011 External Review (DOCX)
- Technical background document for the MS_Combo program (Science Inventory Database)
- Technical guidance for choosing the appropriate stage of a Multistage model for cancer modeling (Science Inventory Database)
Models No Longer Supported
- Repeated Response Measures / ToxicoDiffusion (BMDS 2.7 only)
- Documentation (Science Inventory Database)
- ten Berge Concentration x Time (BMDS 2.7 only; superseded by CatReg 3.0)
- Documentation (Science Inventory Database)
- Multistage Weibull (MSW) Time-to-Tumor
- Software, documentation, and peer review comments (Science Inventory Database). The model executable is a DOS-based application.
- Also available is an R-based graphical tool to generate diagnostic plots with MSW outputs and assist users to assess goodness-of-fit for models fitted using MSW.