Learn About the ISAs

• What is an Integrated Science Assessment?
• Does the ISA include the NAAQS Standards?
• How can I get more involved?
• How do I comment on the current review drafts?

What is an Integrated Science Assessment?

EPA’s mission is to protect human health and the environment. EPA’s Integrated Science Assessments (ISA) Program supports this mission by producing reports that represent concise evaluations and syntheses of the most policy-relevant science for reviewing the National Ambient Air Quality Standards (NAAQS). EPA's NAAQS Standard supports six principal pollutants: ozone, particulate matter, carbon monoxide, sulfur oxides, nitrogen dioxide, and lead. This is important for human health and the environment because numerous sources emit these criteria air pollutants.

ISA assessments:

• Are the preferred source of integrated science used by EPA's NAAQS program
• Are an important source of science on the 6 criteria pollutants used by state and local health agencies, other federal agencies, and international health organizations

The ISA Program is located within EPA’s Center for Public Health and Environmental Assessment (CPHEA) in the Office of Research and Development (ORD). The placement of the ISA Program in ORD ensures that the assessments can be develop independent of their use by EPA’s program and regional offices to set national standards and make environmental decisions.

• About the Center for Public Health & Environmental Assessment
• About the Office of Research and Development

Each ISA is intended to "accurately reflect the latest scientific knowledge useful in indicating the kind and extent of identifiable effects on public health and welfare which may be expected from the presence of [a] pollutant in the ambient air” [42 U.S.C. 7408(b)]. Because the ISA communicates critical science judgments relevant to the NAAQS review, it forms the scientific foundation for the review of the NAAQS standards. All ISAs are vetted through a rigorous peer review process, including review by the Clean Air Scientific Advisory Committee, public meetings and comment periods as announced in the Federal Register for public participation. The process of developing ISAs, including literature review and evaluation, integration of evidence, and characterization of evidence for public health and welfare impacts of criteria air pollutants, is described in the Preamble to the Integrated Science Assessments.

• Learn more about the Clean Air Scientific Advisory Committee (CASAC)

Does the ISA include the NAAQS Standards?

No, these can be found at reviewing national ambient air quality standards (NAAQS): scientific and technical information.

How can I get more involved?

EPA sends out federal register notices (FRN) when the public is invited to comment on ISA draft reports prior to CASAC's external peer review. In addition the EPA Science Advisory Board (SAB) often post other ways for public involvement in advisory activities.

How do I comment on the current review drafts?

EPA will announce the availability of each draft ISA in the Federal Register with detailed steps on how to comment on each report. Typically drafts are released 30-days in advance of the external peer review meeting to allow the public to review and send in comments. All comments should be submitted to the Regulations.gov Web site under the docket ID number listed in each announcement so they are received in time for the meeting. Before the peer review meeting is held, the docket submissions are collected and sent to the reviewers for the discussion. All drafts (first, second, or third) will be filed under the same docket ID for continuity until each assessment is finalized and released on the EPA website.

History of the Integrated Science Assessments

Legislative Requirements

Two sections of the Clean Air Act (CAA, the Act) govern the establishment and revision of the NAAQS. See the process of reviewing the NAAQS for additional information.

• Section 108 of the Act (42 U.S.C. 7408) directs the Administrator to identify and list “air pollutants” that “in [her] judgment, may reasonably be anticipated to endanger public health and welfare” and whose “presence … in the ambient air results from numerous or diverse mobile or stationary sources” and to issue air quality criteria for those that are listed (42 U.S.C. 7408). Air quality criteria are intended to “accurately reflect the latest scientific knowledge useful in indicating the kind and extent of identifiable effects on public health or welfare which may be expected from the presence of [a] pollutant in ambient air…” 42 U.S.C. 7408(b).
• Section 109 of the Act (42 U.S.C. 7409) directs the EPA Administrator to propose and promulgate “primary” and “secondary” National Ambient Air Quality Standards (NAAQS) for pollutants listed under Section 108. Section 109(b)(1) defines a primary standard as one “the attainment and maintenance of which in the judgment of the Administrator, based on such criteria and allowing an adequate margin of safety, are requisite to protect the public health.”
  
  A secondary standard, as defined in Section 109(b)(2), must “specify a level of air quality the attainment and maintenance of which, in the judgment of the U.S. EPA Administrator, based on such criteria, is required to protect the public welfare from any known or anticipated adverse effects associated with the presence of [the] pollutant in the ambient air.”
  
  The requirement that primary standards include an adequate margin of safety was intended to address uncertainties associated with inconclusive scientific and technical information available at the time of standard setting. It was also intended to provide a reasonable degree of protection against hazards that research has not yet identified. These uncertainties are components of the risk associated with pollution at levels below those at which human health effects can be said to occur with reasonable scientific certainty.
  
  Thus, in selecting primary standards that include an adequate margin of safety, the Administrator is seeking not only to prevent pollution levels that have been demonstrated to be harmful, but also to prevent lower pollutant levels that may pose an unacceptable risk of harm, even if the risk is not precisely identified as to nature or degree.